Neurology is regarded by many as one of the most difficult and exacting medical specialties. Students and residents who come to a neurology service for the first time may be intimidated by the complexity of the nervous system through their brief contact with neuroanatomy, neurophysiology, and neuropathology. Many of the difficulties in comprehending neurology can be overcome by adhering to the basic principles of the clinical method outlined in this white paper. Even the experienced neurologist faced with a complex clinical problem depends on this basic approach.